ETH News

ETH Zurich researchers have uncovered a serious side effect of using the CRISPR-Cas gene scissors. A molecule designed to make the process more efficient destroys parts of the genome.

Researchers at ETH Zurich have combined two gene editing methods. This enables them to quickly investigate the significance of many genetic mutations involved in the development and treatment of cancer.

ETH researchers have modified certain bacteria with UV light so that they produce more cellulose. The basis for this is a new approach with which the researchers generate thousands of bacterial variants and select those that have developed into the most productive.

In collaboration with University Hospital Basel, researchers from ETH are investigating the early stages of bladder cancer. Their findings show that future research should also focus on mechanical changes in tumour tissue.

Organoids grown from human stem cells can help provide answers to important medical questions. In a partnership that looks set to profit both sides, ETH professor Barbara Treutlein has teamed up with pharma giant Roche to advance research in this area.

Bioengineer Randall Platt engineers bacteria that can assess the state of our guts. It is hoped this non-invasive technique could eventually be used to develop more effective interventions against malnutrition among children in the Global South.

Estelle Clerc searches remote waters such as the deep ocean for bacteria that can degrade specific pollutants such as microplastics, pharmaceuticals and pesticides.

From new tests and therapies to the fundamental principles of biology: five compelling examples of the benefits of new bioengineering technologies.

Surprisingly little is actually known about how the knee works. ETH professor Bill Taylor plans to change this with a unique technology and a new 22-metre-long experimental facility. ?

ERC Synergy Grants have been awarded to Barbara Treutlein from the Department of Biosystems Science and Engineering and Nicolas Noiray from the Department of Mechanical and Process Engineering, together with their European partners.

Professors Tanja Stadler and Barbara Treutlein awarded the Clo?tta Jubilee Prize for their outstanding achievements in biomedical and developmental biology research.

Researchers at ETH Zurich have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.

The CRISPR-Cas gene scissors enable researchers to study the genetic and cellular causes of autism in the lab ¨C directly on human tissue.

"We will rock you": ETH Zurich researchers are developing a gene switch that triggers insulin release in designer cells by playing certain rock and pop songs.

The ability to utilize a mere single alternative food source is all it takes for diarrhoea causing Salmonella bacteria to bloom when a gut is already colonized by a closely related strain, according to researchers from ETH Zurich. This coexistence enables the exchange of antibiotic resistance.

ETH Zurich professors Mustafa Khammash and Marc Pollefeys are each recipients of a prestigious Advanced Grant currently awarded by the Swiss National Science Foundation, rather than the European Research Council.

A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases ¨C and for those who would like to eat meat, but don¡¯t want to kill animals.

ETH Zurich molecular biologist Mandy Boontanrart is researching gene therapies that could be used to cure two of the most common types of inherited anaemia. She has now developed a promising approach for so-called beta-hemoglobinopathies.

Science often runs ahead of legislation ¨C and this is now also true for research on embryo-like cell aggregates from human stem cells. Bioethicist Alessandro Blasimme of ETH Zurich explains why this controversial topic calls for legal clarity.

The pathogens that cause urinary tract infections are becoming increasingly resistant to antibiotics. ETH Zurich researchers have now developed a rapid test and a new therapeutic approach using bacteria-infecting viruses known as phages.

ETH Zurich and Roche are joining forces in Basel to advance the development of new methods that facilitate the search for medicines. Together, they will train specialists for the biomedical challenges of our time.

Researchers from Basel and Zurich are creating a high-resolution atlas that depicts the development of the human retina. One technique they use is a new method that allows them to visualise more than 50 proteins simultaneously.

A fuel cell under the skin that converts blood sugar from the body into electrical energy sounds like science fiction. Yet it works perfectly, as an ETH Zurich research team led by Martin Fussenegger, Professor of Biotechnology and Bioengineering, has shown.

Cancer patients might one day benefit from being administered immune cells from healthy donors. But as things stand, receiving donor cells can cause severe or even fatal immune reactions. A researcher at ETH Zurich has now developed a technology that avoids these.

Gregor Weiss is fascinated by the inner workings of our cells and is driven by the hope of finding a non-antibiotic therapy for urinary tract infections.

ETH Zurich chemist Freideriki Michailidou is developing novel processes for the sustainable production of fragrance ingredients. As a first step, she studied the scents of rare aromatic plants that grow only on Mount Olympus in Greece.

Researchers at ETH Zurich are planning to use magnetic bacteria to fight cancerous tumours. They have now found a way for these microorganisms to effectively cross blood vessel walls and subsequently colonise a tumour.

Researchers at ETH Zurich are growing human brain-like tissue from stem cells and are then mapping the cell types that occur in different brain regions and the genes that regulate their development.

Scientists have a duty to initiate a dialogue with the public on cellular engineering, says Daniel M¨¹ller. The discussion must be held now ¨C before complex engineered cellular systems are ready for widespread use in humans.

Researchers from ETH Zurich and EPFL are expanding the emerging field of single-cell analysis with a ground-breaking method: Live-seq makes it possible to measure the activity of thousands of genes in a single cell without having to isolate and destroy it.

Most vaccines require constant refrigeration during shipment to remain effective. An international research team led by ETH Zurich has now developed a special hydrogel that vastly improves the shelf life of vaccines, even without refrigeration. The development could save many lives and lower the cost of cold chains.

Researchers from ETH Zurich, the United States and Uganda have identified the gene responsible for resistance in certain cassava cultivars against the devastating cassava mosaic disease. This is an important step for breeding virus-resistant cassava varieties.

Researchers from ETH Zurich, University Hospital of Bern and the University of Bern have equipped gut bacteria with data logger functionality as a way of monitoring which genes are active in the bacteria. These microorganisms could one day offer a noninvasive means of diagnosing disease or assessing the impact of a diet on health.

In a technological breakthrough, researchers at ETH Zurich have announced the development of a new technique that can transplant mitochondria ¨C the tiny powerhouses of the cell ¨C from one living cell to another with unparalleled efficiency.

Four researchers from ETH Zurich have been awarded a Consolidator Grant from the European Research Council (ERC). Since Switzerland is no longer fully associated, they will receive the approximately eight million francs in research funding from the State Secretariat for Education, Research and Innovation (SERI).

Bacteria show great promise as a source of active ingredients. Using computer-based genome analysis, researchers at ETH Zurich have now discovered a new class of natural products that might one day serve as antibiotics.

Load-bearing, lightweight and now also recyclable: researchers led by Professor Paolo Ermanni were presented with the Spark Award in recognition of an innovative process for production of sustainable composite materials. ETH Zurich awarded the prize to their promising invention, with this year marking the tenth time the award has been given.

Tom Edwardson modified a tiny artificial protein structure so it could be used as a vehicle for RNA molecules and other active substances. He now aims to create a spin-off to bring his development to market.

Nako Nakatsuka earned a place on this year¡¯s MIT Technology Review¡¯s Innovators Under 35 list for her invention of a precise chemical biosensor that empowers researchers to better understand brain processes and diseases such as Alzheimer¡¯s, Major Depression, and Parkinson¡¯s.

ETH and the Max Planck Institute for Intelligent Systems are intensifying their partnership to promote doctoral candidates and research: ETH professors Otmar Hilliges, Thomas Hofmann, Andreas Krause and Klaas P. Pr¨¹ssmann are new Max Planck fellows in T¨¹bingen and Stuttgart.

From genetics and personalised medicine to health insurance and climate change: at ETH Week 2021, 120 students from all degree programmes and from 31 countries grappled with the topic of ¡°Health for Tomorrow¡±.

We often hear that Swiss consumers want their agriculture to be free from genetic engineering. But consumer acceptance of genetically modified crops is likely to be higher than the media leads us to believe, Angela Bearth says.

Skintegrity.CH is a transdisciplinary consortium for the largest organ of humans, the skin.

Artificial intelligence can help predict the three-dimensional structure of proteins. Beat Christen describes how such algorithms should soon help to develop tailored artificial proteins.

Is natural always good and artificial always bad? We talked to psychologist Angela Bearth and biotechnologist Sven Panke about science, scepticism, misunderstandings and how language influences the way we think.

Researchers at ETH Zurich have recreated a key step in the evolutionary history of viruses in a laboratory experiment. They succeeded in remodeling a natural protein to create capsids capable of storing genetic material.

ETH Zurich researchers have developed a gene switch that can be operated with the green LED light emitted by commercial smartwatches. This revolutionary approach could be used to treat diabetes in the future.

Machine learning methods help to optimise the development of antibody drugs. This leads to active substances with improved properties, also with regard to tolerability in the body.

Scientists at ETH Zurich are working to develop information-processing switching systems in biological cells. Now, for the first time, they have developed an OR switch in human cells that reacts to different signals.

An extraordinary year is drawing to a close. ETH News takes a look back at the highlights that emerged amidst difficult and unsettling times, at ingenious ideas, fascinating science and solidarity in action during ¨C and despite ¨C the coronavirus pandemic.

Seven ETH researchers can look forward to generous funding for their projects: the European Research Council (ERC) has approved a total amount of around 15 million Swiss francs. ?

ETH researchers have discovered that they can use light-sensitive molecules to switch genetic networks on and off as required. Their finding gives rise to an easy method for dynamically controlling biotechnological substance production.

ETH Zurich researchers can predict how tightly a cell¡¯s protein synthesis machinery will bind to RNA sequences ¨C even when dealing with many billions of different RNA sequences. This binding plays a key role in determining how much of a specific protein is produced. The scientists are developing their prediction model using a combination of synthetic biology experiments and machine learning algorithms.

Soya and clover have their very own fertiliser factories in their roots, where bacteria manufacture ammonium, which is crucial for plant growth. Although this has long been common knowledge, scientists have only recently described the mechanism in detail. With biotechnology, this knowledge could now help make agriculture more sustainable.

A team of researchers led by ETH professor Martin Fussenegger has succeeded in using an electric current to directly control gene expression for the first time. Their work provides the basis for medical implants that can be switched on and off using electronic devices outside the body.

The Basel Botnar Research Centre for Child Health is funding five research projects at ETH Zurich dedicated to the diagnosis and treatment of COVID-19, the disease caused by the coronavirus.

As the world anxiously awaits a remedy for the novel coronavirus, ETH Zurich is also involved in the search for active substances and vaccines. This overview sets out the therapeutic approaches pursued by ETH researchers.

ETH researchers are developing and improving methods to detect the pandemic virus or virus-specific antibodies. With the help of such tests, the scientists are also investigating the details of how the pathogen is spreading. A project overview.

Bioengineers are on the brink of developing artificial organisms that will open up new applications in medicine and industry. Beat Christen discusses their risks and benefits.

A research team with members from ETH Zurich has discovered a new method for turning nearly any object into a data storage unit. This makes it possible to save extensive data in, say, shirt buttons, water bottles or even the lenses of glasses, and then retrieve it years later. The technique also allows users to hide information and store it for later generations. It uses DNA as the storage medium.

ETH researchers are using synthetic biology to reprogram bacterial viruses ¨C commonly known as bacteriophages ¨C to expand their natural host range. This technology paves the way for the therapeutic use of standardized, synthetic bacteriophages to treat bacterial infections.

Researchers at ETH Zurich have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously.

Both nature and technology rely on integral feedback mechanisms to ensure that systems resist external perturbations. ETH researchers have now used synthetic biology to design a new mechanism of this sort from scratch. For the first time, they have introduced it into a living cell as an artificial genetic regulatory network. This will be a useful tool for cell therapy in medicine and for biotechnology.

ETH researchers have integrated two CRISPR-Cas9-based core processors into human cells. This represents a huge step towards creating powerful biocomputers.

Scientists at ETH Zurich have developed a new method that greatly simplifies the production of large DNA molecules containing many hundreds of genes. With this method, they have built the first genome of a bacterium entirely designed by a computer algorithm. The method has the potential to revolutionise biotechnology.

French biochemist Emmanuelle Charpentier, one of the scientists who discovered the Crispr gene editing tool, is being honoured with ETH Zurich¡¯s Richard R. Ernst Gold Medal.

Research findings based on HeLa cells cannot always be reproduced by other scientists. To get to the bottom of this lack of reproducibility, a group of system biologists working with ETH Professor Ruedi Aebersold has embarked on a massive project: molecular cell measurement.

Oskari Vinko and Maximilian Schulz produce software to automate life science laboratory processes, enabling machines to take over the laborious and time-consuming work so bioscientists can focus on the bigger challenges.

Professor Georg Holl?nder and Professor Sai Reddy will head the Botnar Research Centre for Child Health in Basel.

Researchers led by Mustafa Khammash have developed a new method that uses blue light to control the transcription of DNA into RNA in single cells. The technology could also be used in tissue engineering and stem cell research.

A team of researchers from ETH Zurich and the University Children¡¯s Hospital Zurich applied a newly developed editing tool to target and correct genetic mutations. By doing so, the researchers healed mice suffering from a genetic metabolic disorder that also affects humans.

ETH researchers are using the CRISPR-Cas system to develop a novel recording mechanism: the snippets of DNA it produces can provide information about certain cellular processes. In future, this cellular memory might even be used in diagnostics.

Using the famous CRISPR-Cas9 gene scissors, plant biotechnologists at ETH Zurich have been able to improve cassava. The new variety has amylose-free or ¡®waxy¡¯ starch, which is preferred for applications.

Sometimes viruses and bacteria undergo genetic changes that alter their properties and eventually make them more dangerous to humans. Tanja Stadler¡¯s mathematical models shed light on how fast they can mutate and spread.

ETH researchers have genetically modified a key variety of rice, making it very efficient at enriching its grains with iron and zinc.

The digital audio of an entire music album is to be stored in the form of genetic information for the first time, using technology developed at ETH Zurich. Coded in DNA molecules and poured into tiny glass beads, an album by Massive Attack will be preserved ¨C practically for eternity.

ETH researchers working with Martin Fussenegger have developed an early warning system for the four most common types of cancer. Should a tumour develop, a visible mole will appear on the skin.

ETH researchers have developed a new method of crystallising large membrane proteins in order to determine their structure. This will be of benefit to biological research and the pharmaceutical industry.

When the bacterial ecosystem in the intestine is out of balance, there often is no other remedy than a faecal microbiota transplant. Due to the risks of this procedure, researchers from the ETH spin-off PharmaBiome are developing a safe alternative.

ETH researchers have developed a technology platform that allows them to systematically modify and customise bacteriophages. This technology is a step towards making phage therapies a powerful tool for combating dangerous pathogens.

Researchers at ETH Zurich have developed a new type of health-monitoring electrode that exhibits optimum adhesion to skin and can record high quality signals. Two young spin-off founders want to turn it into a marketable product as early as this year.

Martin Fussenegger is convinced that the digital world in which we live will become interlinked with the biological world. He envisages that we will be able to cure diseases with electronic pills in the next 50 years.

ETH researchers have developed a biocompatible ink for 3D printing using living bacteria. This makes it possible to produce biological materials capable of breaking down toxic substances or producing high-purity cellulose for biomedical applications.

ETH researchers have developed a method that allows large amounts of genetic information to be compressed and then decompressed again in cells. This could aid in the development of new therapies.

ETH researchers have reprogrammed normal human cells to create designer immune cells capable of detecting and destroying cancer cells.

ETH researchers have developed a scale for measuring cells. It allows the weight of individual living cells, and any changes in this weight, to be determined quickly and accurately for the first time. The invention has also aroused significant interest both in and outside the field of biology.

Scientists have identified the mechanism that allows fluorescent proteins to switch colour in two phases. They are thereby laying the groundwork for new applications in microscopy and functional analyses in biological research.

ETH Zurich researchers have identified all the genes required by a bacterium to use methanol as a food source. The results will help scientists advance the use of this resource in the field of biotechnology.

ETH researchers have developed a new rice variety that not only has increased levels of the micronutrients iron and zinc in the grains, but also produces beta-carotene as a precursor of vitamin A. This could help to reduce micronutrient malnutrition, or ?hidden hunger?, which is widespread in developing countries.

ETH researchers have created an effective weapon against the plant disease fire blight and a new method for detection of Salmonella. Both are based on particular viruses that attack only one species of bacteria.

Ten years ago, ETH Zurich established its first and only department outside Zurich: the Department of Biosystems Science and Engineering in Basel. ETH will soon expand its outpost. The construction of a new department building on the Sch?llem?tteli campus will bring it right next to the University of Basel.

ETH microbiologists have succeeded in showing that nature produces one of the most complex known bioactive natural products in a staggeringly simple way. The molecule originates from bacteria living in sea sponges. In future, it may be possible to produce the agent very easily using biotechnology, making it an interesting avenue for cancer research.

Researchers have used the simplest approach yet to produce artificial beta cells from human kidney cells. Like their natural model, the artificial cells act as both sugar sensors and insulin producers.

Researchers at ETH Zurich have produced starch in yeast - the first time this has been achieved in a non-plant organism. The new model system now makes it easier for them to investigate how starch is formed and what role is played by the enzymes involved. In future, it may be possible to use yeast to trial specific modifications of starch.

ETH scientists have constructed bacteria in which growth can be controlled fully automatically by a computer. The interface between computer and bacteria is based on red and green light. The approach could help to optimise the biotechnological production of molecules.

ETH researchers have synthesised fatty acids in the laboratory that result from oxidative stress in the body. The laboratory variants turned out to be more potent anti-inflammatories than the natural ones, and have now been patented.

Vitamins, medication, solvents, crop protection products and polymers ¨C in future, it will be possible to manufacture many of these from wood waste. The processes will also be at least as cost-effective, environmentally friendly and safe as current oil-based processes. This has been demonstrated by an international team of researchers headed by ETH Zurich scientists.

A Nobel prizewinning idea bears entrepreneurial fruit: an ETH Pioneer Fellow is applying knowledge about G-protein-coupled receptors to market a novel process for testing drugs.

Researchers at ETH Zurich have managed to use a synthetic genetic program to instruct stem cells taken from fatty tissue to become cells that are almost identical to natural beta cells. This brings them a major step closer to a personal repair kit for diabetes sufferers.

ETH researchers develop an integral control loop for living cells extending established tools from control engineering. This could help the cells produce precisely controlled amounts of a product.